Blar i forfatter "Lamsal, Apsana"

Viser treff 1-3 av 3

    • Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours 

      Bokil, Ansooya Avinash; Børkja, Mathieu; Wolowczyk, Camilla Izabel; Lamsal, Apsana; Prestvik, Wenche S.; Nonstad, Unni; Pettersen, Kristine; Andersen, Sonja Benedikte; Bofin, Anna M.; Bjørkøy, Geir; Hak, Sjoerd; Giambelluca, Miriam Soledad (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-18)
      Background: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity have limited their role as prognostic markers and therapeutic targets. <p><p>Methods: To identify markers associated with myeloid cells in metastatic tumours, we compared transcriptomic ...

    • Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer 

      Lamsal, Apsana; Andersen, Sonja Benedikte; Johansson, Ida; Vietri, Marina; Bokil, Ansooya Avinash; Kurganovs, Natalie Jayne; Rylander, Felicia; Bjørkøy, Geir; Pettersen, Kristine; Giambelluca, Miriam Soledad (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved understanding of anti-cancer immune responses in the TME, it is still unclear how immuno-suppressive TME are formed and how some cancer cells survive and metastasize.<p> <p>Methods ...

    • Study of human PRKAR1A and its role in autophagy 

      Lamsal, Apsana (Master thesis; Mastergradsoppgave, 2018-05-11)
      The human PRKAR1A gene is a 381- amino acid protein encoding the regulatory subunit (RIα) of the cAMP dependent Protein Kinase A (PKA). The main function of PRKAR1A is to regulate the catalytic activity of PKA. PRKAR1A is shown to regulate autophagy via association with mTOR kinase and colocalization with the autophagy marker proteins LC3B, Rab7 and Rab9. Contradictory findings regarding the ...